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pentobarbital will lower the extent or result of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.pentobarbital will lessen the extent or impact of irinotecan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lower the level or result of sax